STUDIES ON THE DISTRIBUTION AND EXCRETION OF PHENYLMERCURY ACETATE
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<SUP>203</SUP>Hg-phenylmercury acetate (<SUP>203</SUP>Hg-PMA) was given to mice, and its retention, excretion and distribution were investigated. Furthermore various drugs were examined for <SUP>203</SUP>Hg-expelling effect.<BR>1. Retention : the retention after the s.c., i.p. and p.o. administration were daily explored. The biological half-life was short, about 1-2 days in all cases.<BR>2. Excretion : The daily excretion was usually high in feces and low in urine.<BR>3. Distribution : The radioactivity after i.p. administration was highest in the kidney already at 1 hour, and attained the peak at 4 hours. At 1 hour, next in order were the pancreas, blood, liver, spleen, brain successively. At 24 hours, the liver exceeded pancreas.<BR>The subcellular distribution of <SUP>203</SUP>Hg-PMA in the liver and kidney 24 hours after i.p. administration was greater in the supernatant fraction in both organs than the other fractions.<BR>4. Effects of administration of various drugs : In 3 day experiments on the whole-body retention of <SUP>203</SUP>Hg-PMA was decreased by BAL only. L-CySH·Gly., EDTA, ZnSO<SUB>4</SUB> were often found to increase <SUP>203</SUP>Hg retention. BAL decreased <SUP>203</SUP>Hg activity among the kidney, liver, pancreas, spleen, blood, but it significantly increase only the cerebral concentration of <SUP>203</SUP>Hg. 2-Mercaptopropionyl glycine decreased <SUP>203</SUP>Hg concentration in the pancrease and spleen in the experiment after i.p. administration of <SUP>203</SUP>Hg-PMA, and in the kidney in experiment after oral administration of<SUP>203</SUP>Hg-PMA.<BR>5. Effect of starvation : The fecal excretion of <SUP>203</SUP>Hg was decreased and the retention of it was increased by the starvation, and they were recovered by feeding.
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北関東医学会 | 論文
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