ELIMINATION OF DRUG-RESISTANCE IN STAPHYLOCOCCUS AUREUS BY TREATMENT WITH ELEVATED TEMPERATURE

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Loss of resistance to antibiotics during the culture at a higher temperature was studied on 18 multiply resistant strains of Staph. aureus. After incubation of 43°±0.5°C for 6 hours, 13 out of 18 strains lost their resistance to antibiotics. When the resistant Pattern of the 13 strains was analysed, penicillin resistance was lost in 10 out of 13 penicillin resistant strains, mercury resistance in 10 out of 10, erythromycin resistance in 1 out of 3, streptomycin resistance in 4 out of 11, and tetracycline resistance in 1 out of 12. Loss of resistances to penicillin, mercury and erythromycin were always associated with each other excepting one strain resistant to moderate amount of penicillin which lost resitance to mercury alone. Resistances to streptomycin, tetracycline and penicillin were lost independently. The growth rate was found to be different not only between incubating temperature of 43°C and 37°C, but also betweenresistant strains and their sensitive variants. These difference could lead to selection of the drug-sensitive variants as a result of growth at high temperature. Abscence of correlation between the occurance of the drug-sensitiv evariants and the growth rate at high temperature leaves open the question whether or not loss of resistance to antibiotics is induced by dilution of plasmid resulting from cell division.
北関東医学会の論文