Insulin-mimetic action of vanadyl complexes.
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Blood glucose levels of streptozocin (STZ)-induced diabetic rats dropped from hyperglycemic levels to hypoglycemic levels within 24-48h after treatment with vanadyl sulfate (VS) by intraperitoneal injection. Results of the glucose tolerance test indicated that the diabetes was completely improved by VS administration, but the plasma insulin levels were still low. Determination of both vanadyl and total vanadium in VS-treated STZ-rats suggested that the vanadyl is possibly in a pharmacologically active form. Several vanadyl complexes such as vanadyl-cysteine methyl ester (VCys), -oxalate (VOX), -malonate (VMA), -salicylaldehyde (VSA), and -(+)-tartarate (VTA) were tested by oral administration. The order of normoglycemic effect in STZ-rats was VA>VCys>VTA>VSA>VOX. The action of VCys was dose-dependent in the range of 1-10mgV/kg body weight, and this complex was shown to be a potent agent in restoring the normoglycemic level in STZ-induced diabetic rats.
- 日本酸化ストレス学会の論文
日本酸化ストレス学会 | 論文
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