Delayed Recovery of Rat Liver Microsomal Function after Relief of Biliary Obstruction
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Structure and function of rat liver microsomes were studied during biliary obstruction and after its relief by external drainage. The concentration of serum bilirubin and the activity of serum glutamic-oxaloacetic transaminase rapidly decreased to near normal levels after the drainage. The percentage of smooth endoplasmic reticulum to the total endoplasmic reticulum increased during the biliary obstruction but it returned to normal one day after the drainage. In contrast, the specific content of cytochrome P-450 and the specific activity of NADPH-cytochrome c reductase in the microsomes did not recover to normal ones even 10 days after the drainage. These results demonstrate that the dysfunction of liver microsomes is prolonged after bile drainage despite recovery of serum biochemical indices and ultrastructural changes to the normal state.
- 日本酸化ストレス学会の論文
日本酸化ストレス学会 | 論文
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