Effectiveness of Carbohydrates Mixtures as the Energy Source for Total Parental Nutrition:A Comparative Study in Postoperative Rabbit Model

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This study was designed to evaluate the metabolic and hormonal effects of various combinations of carbohydrate loads containing glucose, fructose, and xylitol in a rabbit model utilizing laparotomy of depressed glucose metabolism.The animals were divided into eight groups according to carbohydrate ratios of the total parenteral nutrition (TPN) solution. TPN with a nonprotein calorie ratio of 150 was administered for three days at an isocaloric dose of 112kcal/kg/day. The plasma glucose level and urinary excretion rates were the lowest in the group receiving a 8:4:2 combination of glucose, fructose, and xylitol (GFX842). The daily nitrogen balance for this group was significantly higher than that of groups with other carbohydrate combinations.Solutions of 14C-labeled glucose, fructose, and xylitol in various ratios were also administered to evaluate the usefulness of the GFX842 mixture from the aspect of efficient energy utilization. Of the various combinations GFX842 was found to be the most effective in utilization of carbohydrates, as judged from the expired 14CO2 excretion rate, plasma level of [14C]glucose, [14C]fructose, and [14C]xylitol, and the endogenous glucose level.These data imply that the ratio of the carbohydrates in the GFX842 mixture is the most important factor with regard to the control of plasma glucose and the utilization of carbohydrates in the state of impaired glucose tolerance.
日本酸化ストレス学会の論文