:Part 1. Effects of Various Nutritional Conditions on Serum and Liver Cholesterol Levels in Rats Fed Low-Cholesterol Diet
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概要
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The aim of the present study was to clarify the effects of replacing cornstarch with sucrose in a cholesterol-free diet on serum and liver cholesterol levels in rats of the Sprague-Dawley strain under various dietary conditions and for different feeding periods.The results obtained were as follows: There was no difference between the growth rate produced by a diet with sucrose and that produced by a diet with cornstarch—both as the sole carbohydrate source—for 10 to 28 days' feeding. On the other hand, body weight gain and tissue weight of animals were significantly affected by diets composed of different amounts of milk casein. In a series of experiments, sucrose in the diet led to greater enlargement of liver or perirenal adipose tissue than did cornstarch. Nutritional factors, such as the dietary source and levels of carbohydrate, fat and protein showed no demonstrable effects on the concentrations of cholesterol in serum, independently. As for the interaction of dietary components, in a diet with adequate protein, serum cholesterol tended to increase with sucrose regardless of the difference of dietary fat sources. Conversely, in a low protein diet, serum cholesterol tended to increase with the starch. The whole amount of liver cholesterol was remarkably influenced by dietary carbohydrate sources. Concomitant feeding of either the sucrose diet with lard or the starch diet with safflower oil significantly elevated the cholesterol contents of the liver. When sucrose in the diet replaced the starch, higher triglyceride concentrations in both serum and liver were observed.
- 特定非営利活動法人 日本栄養改善学会の論文
特定非営利活動法人 日本栄養改善学会 | 論文
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