Bone Mineral Content and Serum 25-hydroxycholecalciferol
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概要
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Previously, we have reported that the bone mineral content in Japanese decreased with aging and that the loss of bone mineral content in the aged female with fractures was significantly greater than that in the aged matched females without fracture.Therefore, the purpose of the present study is to clarify the role of endogenous estradiol (E2) and 25-hydroxycholecalciferol (25-OHD3) on the loss of bone mineral (RMC) in the aged females.In fifty three female subjects over 60 years, radial mineral contents were measured using photon absorption method developed by Norland-Cameron. Serum E2 and 25-OHD3 levels were measured by the specific radioimmunoassay and competitive protein binding assay, respectively. Serum 25-OHD3 levels showed significant positive correlation with serum calcium levels.However, there was no significant correlation between the age of the subjects and serum E2 and serum 25-OHD3 levels, respectively. Radial mineral contents were significantly correlated with age (r=-0.408, P<0.01), serum Ca (r=0.345, P<0.02), serum E2 levels (r=0.396, P<0.01) and serum 25-OHD3 (r=0.510, P<0.01), respectively.In the aged females with fractures, RMC, serum Ca levels and serum 25-OHD3 levels were significantly smaller than those in the age matched females without fracture.On the other hands, serum E2 levels in the aged female with fractures did not differ from those in the age matched females without fracture.In conclusion, in the aged females it was clearly demonstrated that the low serum 25-OHD3 level was intimately correlated with the pathological osteoporosis characterized by the fractures.
- 社団法人 日本老年医学会の論文