Re-evaluation on lung metastases by local hyperthermia in Lewis lung carcinoma.

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Local hyperthermia at 43.5 °C without raising body-temperature above 40 °C was performed in mice with Lewis lung tumors. Effects of the hyperthermia on tumor growth and development of metastases were studied. The growth of the primary tumors was inhibited, but the growth delay was only within a day. With the tumor-bearing mice, the number of large-sized metastatic lung colonies, which were considered to devolop before or at the hyperthermia, were not different from control group, but the number of small-sized colonies considered to develop after the hyperthermia were significantly decreased. With non-tumor-bearing mice by resection of the primary tumors after the hyperthermia, total number of lung colonies were not signifiantly different from 37.5 °C of control group.There were no differences on tumor growth and development of metastases among the tumors ranging from 150 to 800 mm<SUP>3</SUP> in volume at the hyperthermia and among the tumors growing in intracutis, subcutane or intramuscle. There was also no influence on development of metastases with handling of the mice at the hyperthermia.
日本ハイパーサーミア学会の論文