Lung carcinoma induction in syrian golden hamsters by intratracheal instillation of 1,6-dinitropyrene.
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概要
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The carcinogenicity of a potent mutagen, 1, 6-dinitropyrene (1, 6-DNP), was examined by intratracheal instillation into non-inbred Syrian golden hamsters of both sexes. Animals were treated with 0.5mg of 1, 6-DNP suspended in 0.2ml of saline intratra-cheally once a week for 26 weeks. Lung carcinomas developed in experimental weeks 20-48 in 100 and 90%, respectively, of the male and female hamsters treated with 1, 6-DNP. Besides lung carcinomas, myeloid leukemias developed in 60% of both males and females treated with 1, 6-DNP. No tumors were found in control hamsters.
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