An approach to computerized analysis of serum protein electrophoresis.
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概要
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We have tried to establish an expert system which is based mainly on computerized analysis of serum protein electropherogram to comprehend conditions of patients. The method consists of the quantitative analysis of digital signals from the automated electrophoresis system and of the total visualization of parameters. Seventeen parameters were selected, i. e., fractions (5), A/G ratio, total protein (TP), top & bottom positions of each fraction (9) and half width of albumin fraction. A standard normal pattern, which becomes a base of a superimposed pattern, was derived from 562 electropherograms of normal samples in absolute value equalized by the total protein. And the standard basic parameters in SD index were obtained by calculation of (measured value-mean value)/standard deviation. The SD index was comparable to each parameter in the common unit. The range over ±3SD was defined as abnormal level for each parameter. Application of this system to typical abnormal serum protein patterns showed that it was very effective to demonstrate their abnormalities both quantitatively and graphically.
- 日本電気泳動学会の論文
日本電気泳動学会 | 論文
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