Changes of proteinase inhibitors in malignant diseases
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Serum proteinase inhibitors such as C1S-inhibitor (C1S-INH), α1-antitrypsin (α1-AT), antithrombin III (AT-III) and α2-macroglobulin (α2-M) were measured in 156 patients with malignant tumors of various organs.Results;1. Generalized findings in all patients examined: C1S-INH and α1-AT increased and AT-III decreased as the stage of tumors progressed. A significant increase of α2-M was found exclusively in the male patients, but changes became unremarkable following the progression of illness.2. Changes in each patient group with tumors of different organs: (a) α2-M significantly increased also in the female patients in advanced stage of cancer of the lungs. (b) AT-III rather increased in cancer of the cervix uteri. (c) α2-M significantly increased even in earlier stage of cancer of the urinary bladder. (d) AT-III remarkably decreased in cancer of the prostate.These changes of serum proteinase inhibitors are assumed to contribute beneficial environment for the growth of tumors.
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