Biological effective concentration of Pancuronium in blood
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In the spectrofluorimetric method, Pancuronium Bromide and its metabolites were taken into acount for the Pancuronium Bromide concentration in the blood. Pancuronium bromide were also known to be inactivated by binding to albumin and dissolving into lipid.We studied the biological effective concentration of Pancuronium Bromide by means of frog-abdominal rectus muscle contraction produced by Acetylcholine. Pancuronium Bromide showed the inhibition of the muscle contraction by Acetylcholine, and it's action was lessen by serum proteine. Therefore it was concluded that the effective concentration of Pancuronium Bromide was depended on serum protein concentration. Effective concentrations of Pancuronium Bromide in 5, 30, 60 minutes following bolus intravenous injection of 4mg of Pancuronium Bromide to adult patient were 0.48±0.037μg/ml, 0.40±0.031μg/ml and 0.30±0.090μg/ml, and total Pancuronium Bromide concentrations were 0.63μg/ml, 0.52μg/ml and 0.39μg/ml respectively.
- 日本臨床麻酔学会の論文
日本臨床麻酔学会 | 論文
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