The Effect of 2,4-Dichlorophenol on Lipid Peroxidation in Tissues of Guinea Pigswith Different Ascorbic Acid Intake.
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概要
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Chlorinated phenols are widely used in the manufacture of biocides and wood preservatives. 2, 4-dichlorophenol administered perorally 3 times a week at a dose of 40 mg in 0.2ml of olive oil per kg of body weight to guinea pigs increased lipid peroxidation in liver and adrenals after 2 weeks of treatment. A high intake of ascorbic acid (50mg/animal/day) significantly decreased lipid peroxidation in the liver of 2, 4-dichlorophenol treated guinea pigs in comparison to guinea pigs with low ascorbic acid intake (2mg/animal/day). 2, 4-dichlorophenol accumulation was also decreased in the liver of animals with high ascorbic acid intake. Increased daily intake of vitamin C to persons involved in production and use of chlorophenoxy herbicides is recommended.
- 独立行政法人 労働安全衛生総合研究所の論文
独立行政法人 労働安全衛生総合研究所 | 論文
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