Lymphocytic interstitial pneumonia associated with a marked increase in monoclonal IgM-.KAPPA.-type rheumatoid factor and serum CA19-9.
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A 62-year-old Japanese female was admitted due to dyspnea. She showed a marked increase in CA19-9 (maximum, 192, 000 U/ml) and monoclonal IgM- κ type rheumatoid factor (RF) activity. The patient died of respiratory failure 3 months later. Autopsy findings revealed an infiltration of IgM- κ -positive plasma cells in the pulmonary interstitium, and therefore a diagnosis of lymphoid interstitial pneumonia (LIP) was made. The bronchoepithelial cells were stained with monoclonal antibody-reactive with CA19-9 antigen. This is the first documented LIP, associated with a marked increase in monoclonal IgM- κ type RF and CA19-9 in the serum.
- 社団法人 日本内科学会の論文
社団法人 日本内科学会 | 論文
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