Contribution of intracellular stored calcium to contractile activation in contractures of stomach circular muscle of Bufo vulgaris formosus.
スポンサーリンク
概要
- 論文の詳細を見る
Contractile responses of stomach circular muscle of Bufo to high-K, to acetylcholine (ACh) in normal Ringer or in high-K solution, and to calcium in Ca-free high-K solution showed a phasic contraction which relaxed completely in 30-45sec. K-induced contracture was abolished in Ca-free solution containing 1mM ethylene glycol bis(β-aminoethyl ether)-N, N′-tetraacetic acid (EGTA) within 20sec, while ACh-induced contracture was not abolished and 10-25% of control tension was kept up to 40sec. This response increased to 40-50% when all extracellular Na was replaced with tris(hydroxymethyl)aminomethane (Tris). K-induced contracture was inhibited completely by 1mM La. ACh-induced contracture in the muscle depolarized by high-K solution was dependent on the depolarization time, 0-10, 60-70, and nearly 100% of control after 1, 3, and 10min depolarization, respectively. These ACh-induced contractures were not inhibited by 1mM EGTA or La. All contractures mentioned above were markedly inhibited by 5mM procaine. These results suggest that activation of both contractures induced by high-K and ACh were, at least partly, dependent on the Ca at the intracellular Ca storage sites. Ca-induced contracture was dependent on depolarization time as was ACh-induced contracture, when the muscle was depolarized by Ca-free high-K solution without pre-treatment with Ca-free Ringer solution. These results suggest that activation of Ca-contracture is also dependent on intracellular stored Ca.
- 日本生理学会の論文
日本生理学会 | 論文
- 大脳基底核の機能 : パーキンソン病との関連において
- 低温環境下で飼育したカエルの前根電位の変化
- 2,5-ヘキサンジオン投与によるラット会陰筋のミオシン重鎖アイソフォーム成分の変化
- 後肢懸垂によるラットヒラメ筋線維のミオシン重鎖アイソフォーム発現パターンの変化
- 生体における酸素の効率的利用機構