EFFECT OF INTRACAROTID INJECTION OF PITRESSIN, PITOCIN, EPJNEPHRINE AND ACETYLCHOLINE ON ACTH RELEASE IN RATS
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ACTH releasing activities of epinephrine, acetylcholine, Pitressin, synthetic lysine vasopressin and Pitocin injected into the carotid artery of rat were studied.<BR>Pitressin and synthetic lysine vasopressin possessed the strongest potencies.<BR>The dose threshold of Pitressin to induce an appreciable ACTH release fell between 40 and 80mU per rat.<BR>Pitressin incubated with a kidney homogenate lost its ACTH releasing activity.<BR>The rise in blood ACTH level following an intracarotid injection of 5ug. epinephrine was not altered when 40mU of Pitressin was administered simultaneously.<BR>The authors are indebted to Prof. VINCENT DUVIGNEALD for the synthetic lysine vasopressin employed in this experiment. This study was supported by U. S. P. H. S. grant A-256.
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