上顎歯肉腫瘤として発見された腎細胞癌多発転移の1例と文献的考察

概要

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Oral metastasis of renal cell carcinoma is rare. We report a case of renal cell carcinoma with multiple metastases that initially presented as a tumor of the upper gingiva. The patient was a 66-year-old man who visited our department because of a swelling of the upper anterior gingiva. Biopsy was performed, and gingival metastasis from renal cell carcinoma was strongly suspected on histopathological examination. Computed tomography (CT) demonstrated a large mass of the right kidney and multiple metastases of the lungs. Renal cell carcinoma with metastases to the lungs and upper gingiva was diagnosed. Resection of the gingival tumor was performed because of its rapid growth and difficulties in eating. Nephrectomy was performed at the same time. The patient then underwent administration of sunitinib. Finally, he died of pulmonary metastasis at 7 months after the surgery. However, surgical resection of gingival metastasis and dentures for the resected part are useful for improving patients quality of life. We reviewed the literature on oral-region metastasis of renal cell carcinoma, and found 29 cases reported in Japan.
日本口腔診断学会の論文