Aspergers syndrome with unusual cerebral pathology: Case report and literature review

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• A case of Aspergers syndrome with unusual cerebral pathological changes is reported. A 22-year-old male had been having diagnostic Aspergers syndrome since the age of eight and had epilepsy during the past two years. Radiological studies revealed a focal intra-axial cortical and subcortical cerebral lesion with hyper-intensity and non-enhancing contrast in the left frontal lobe. Histological and immunohistochemical studies demonstrated that the lesion consisted of cortical laminar disorganization, neuronal dysmorphism and increased heterotopic neurons in sub-cortical white matter. To our knowledge, this is the first case of Aspergers syndrome with focal cerebral pathological abnormalities rather than mini-columnar changes and the gyrial malformation reported in the literature.

• 特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会の論文

特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会 | 論文

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