ラット肩関節炎モデルの行動 • 疼痛評価と経皮吸収型抗炎症剤の効果の検討
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概要
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<B>Background:</B> The purpose of this study was to evaluate the behavior and the inflammatory cytokines in the rat shoulder arthritis model.<BR><B>Methods:</B> Seventy Sprague-Dawley rats were divided into three groups 1: control group (before experiment), 2: Adjuvant group: Adjuvant (50ul) was injected into the right shoulder joint, and the shoulder arthritis model was created. 3: Patch group: The shoulder arthritis model with percutaneous administration of NSAIDs. Standing time, print area and contact intensity were examined using Cat walk as a behavioral evaluation. Moreover, inflammatory cytokine (IL-1β) was measured from the synovia of the subacromial bursa and the glenohumeral joint using the ELISA method.<BR><B>Results:</B> Standing time, print area and contact intensity in the Adjuvant group were decreased compared to the control group. Standing time, print area and contact intensity in the Adjuvant + patch group was increased compared to the Adjuvant group. On the other hand, Il-1β in the Adjuvant group was increased compared to the control group. Il-1β in the Adjuvant + patch group was decreased compared to the Adjuvant group. Significant difference was not observed between the Adjuvant+patch group and the Control group.<BR><B>Conclusion:</B> These datum showed that percutaneous administration of NSAIDs was effective in the reduction of the inflammatory cytokines (Il-1β). These datum also showed that the inflammatory cytokines (Il-1β) may be the one of the pain mechanisms in shoulder arthritis.
- 日本肩関節学会の論文
日本肩関節学会 | 論文
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