Effects of Ezetimibe on Serum Polyunsaturated Fatty Acids in Patients With Coronary Artery Disease
スポンサーリンク
概要
- 論文の詳細を見る
Residual risk of cardiovascular disease might stem, at least partially, from low serum concentrations of n-3 polyunsaturated fatty acid (PUFA). The purpose of this study was to evaluate the effects of ezetimibe on serum lipids and PU-FAs in patients with coronary artery disease who were intolerant of new or high-dose statin therapy. The study population consisted of 13 patients who were intolerant of new statin therapy and 10 patients who were intolerant of high-dose statin therapy for the treatment of low-density lipoprotein (LDL) cholesterol. Patients who were intolerant of high-dose statin therapy continued taking a statin, but at a lower dose during the study period. Blood samples were collected before and 12 weeks after ezetimibe (10 mg). We measured serum lipids and PUFAs including dihomo-γ-linolenic acid, arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid. Ezetimibe significantly decreased LDL cholesterol (138 ± 19 mg/dL to 97 ± 34 mg/dL, <I>P</I> < 0.01), but did not significantly affect high-density lipoprotein cholesterol, triglyceride, or any of the PUFAs measured during the follow-up period. Consequently, it did not affect the ratio of EPA to AA (0.40 ± 0.17 to 0.43 ± 0.18, <I>P</I> = ns) or the ratio of n-3 PUFA to n-6 PUFA (1.10 ± 0.39 to 1.09 ± 0.36, <I>P</I> = ns) during the follow-up period. Ezetimibe in combination with a low-dose statin, or as monotherapy in statin-intolerant patients, decreased LDL cholesterol, but did not significantly affect serum PUFA concentrations in patients with coronary artery disease.
- 一般社団法人 インターナショナル・ハート・ジャーナル刊行会の論文
一般社団法人 インターナショナル・ハート・ジャーナル刊行会 | 論文
- Influence of Renal Dysfunction on Clinical Outcomes in Patients With Congestive Heart Failure Complicating Acute Myocardial Infarction
- Three-Dimensional High-Density Bipolar Contact Mapping of Left Atrial Endocardial Activation During Sinus Rhythm in Patients With Atrial Fibrillation
- Rate-Dependent Electrophysiologic Effects of the Class III Antiarrhythmic Drugs Nifekalant, Amiodarone, and Ibutilide on the Atrium in Patients With Persistent Atrial Fibrillation
- Prediction of Coronary Artery Stenosis at Rest in Patients With Normal Left Ventricular Wall Motion:Segmental Analyses Using Strain Imaging Diastolic Index
- Subclinical Tonic-Clonic Epileptic Seizure Detected by an Implantable Loop Recorder