Associations Between High-sensitivity C-reactive Protein and Metabolic Risk Factors, Metabolic Syndrome, Diabetes, and Chronic Kidney Disease in Japanese Men and Women

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概要

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• <B>Background</B> The associations between hs-CRP and metabolic risk factors, metabolic syndrome (MS), diabetes, and chronic kidney disease (CKD) were poorly studied in Japanese.<B>Methods</B> MS-related risk factors, MS defined by revised National Cholesterol Education Program (NCEP) criteria for Japanese, Japanese metabolic syndrome (JMS), diabetes, and CKD were compared between subjects with the highest quartile of hs-CRP (Q4) and those with the lowest quartile of hs-CRP (Q1) using medical check-up data from 1880 men and 1079 women. Diabetes was defined as fasting glucose ≥126 mg/dl and/or antidiabetic medication. CKD was defined as estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 and/or proteinuria.<B>Results</B> BMI, body fat %, waist circumference, systolic and diastolic BP, fasting glucose, TG, hs-CRP, gamma glutamyltransferase, ALT, LDL cholesterol, uric acid, WBC count, and heart rate were significantly higher and HDL cholesterol and eGFR were significantly lower in MS subjects than in non-MS subjects in both men and women. % vital capacity was significantly lower in MS subjects than in non-MS subjects in men. The prevalence of MS, JMS, and CKD was significantly higher in Q4 than in Q1 in both men and women and the prevalence of diabetes was significantly higher in Q4 than in Q1 in men, but not in women.<B>Conclusion</B> The prevalence of MS, JMS, and CKD was significantly higher in Q4 than in Q1 in both men and women and the prevalence of diabetes was significantly higher in Q4 than in Q1 in men. (Ningen Dock 2010; 24: 13-20)

• Japan Society of Ningen Dockの論文

著者

• Ryu Kawai

  Medical Check-up Center, Tachikawa Medical Center

• Eiji Oda

  Medical Check-up Center, Tachikawa Medical Center

関連論文

• Uric Acid Only Among Metabolic Risk Factors Independently Associated with Impaired Fasting Glucose in Apparently Healthy Non-diabetic Japanese Women Older Than 50 Years
• Uric Acid Only Among Metabolic Risk Factors Independently Associated with Impaired Fasting Glucose in Apparently Healthy Non-diabetic Japanese Women Older Than 50 Years
• Associations Between High-sensitivity C-reactive Protein and Metabolic Risk Factors, Metabolic Syndrome, Diabetes, and Chronic Kidney Disease in Japanese Men and Women
• A Review of Metabolic Syndrome as Systemic Pre-disease State Developing Through Adipose Tissue Disease

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