Association between Serum Uric Acid and Change in Estimated Glomerular Filtration Rate after 10 years

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Objective: Chronic kidney disease (CKD) is a risk factor for cardiovascular disease, and elevated serum uric acid (SUA) has been reported to be associated with the progression of CKD. We therefore examined the prevalence of CKD and whether higher SUA decreased the estimated glomerular filtration rate (eGFR) after 10 years.Methods: The subjects were 5,629 men and 3,711 women who visited our hospital for a health check-up in 2008. The prevalence of CKD and the relationship between SUA and eGFR were investigated. Subjects who had participated our 'human dry dock' program in both 2008 and 1998 and had no renal dysfunction (60≤ eGFR <90) in 1998 were divided into 2 groups: no remaining renal dysfunction group (N-group) and renal dysfunction group (D-group). We compared the changes in their eGFR and SUA after the 10-year interval.Results: The proportion of subjects with CKD was 13.9%. SUA in 1998 was correlated negatively with eGFR 10 years later (men: r=-0.17, p<0.01, women: r=-0.13, p<0.01). SUA was already higher in the D-group than that in the N-group in 1998. SUA increased after 10 years in the D-group and in N-group females, and decreased in N-group males. Urine pH increased only in N-group males, so it was higher than in D-group males in 2008.Conclusion: SUA was correlated negatively with eGFR after 10 years, and higher SUA levels appeared to be related to the decrease in eGFR suggesting that SUA may be a predictive parameter for CKD.