Impact of Insufficient Insulin Secretion on Subclinical Glucose Dysregulation

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概要

• 論文の詳細を見る

• <B>Background</B> To elucidate the impact of insufficient insulin secretion on subclinical glucose dysregulation in association with increased insulin resistance and aging.<B>Methods</B> We conducted a cross-sectional study of 3950 Japanese subjects using homeostasis model assessment (HOMA)-derived indices. We compared β-cell function according to insulin resistance or age groups. Interaction between insulin resistance and aging on β-cell function was assessed using two-way analysis of variance (ANOVA).<B>Results</B> Increased insulin resistance resulted in higher blood glucose levels and apparently higher insulin secretion, but compensatory insulin secretion was considered insufficient to suppress subclinical blood glucose elevation. Along with aging, fasting blood glucose became higher without changes in serum insulin levels and HOMA-derived indices for β-cell function significantly decreased. Two-way ANOVA revealed that insulin resistance and aging independently influenced β-cell function and the effects of insulin resistance on β-cell function were more dominant than those of aging.<B>Conclusion</B> Our study shows that β-cell dysfunction is a major contributor in determining glucose disposal and insufficient insulin secretion is already present even when glucose levels rise into the "highnormal" range. Insulin secretion should be evaluated in relation to insulin resistance, as the observed insulinsecretion may be insufficient to adjust plasma glucose concentrations. (Ningen Dock 2011; 25: 37-44)

• 日本人間ドック学会の論文

著者

• Eiko Takahashi

  Department of Clinical Health Science, Tokai University School of Medicine

• Chizumi Yamada

  Department of Clinical Health Science, Tokai University School of Medicine

• Fumiyo Inabe

  Department of Clinical Health Science, Tokai University School of Medicine

• Toshitake Mitsuhashi

  Department of Clinical Health Science, Tokai University School of Medicine

• Noboru Hiratsuka

  Department of Clinical Health Science, Tokai University School of Medicine

• Nami Araida

  Department of Clinical Health Science, Tokai University School of Medicine

関連論文

• Gender Difference in High-density Lipoprotein Cholesterol in Japanese
• Determination of Optimal Cut-off Points for Obesity-related Measures of Metabolic Syndrome Based on Insulin Resistance
• Relationship between Thyroid Dysfunction and Serum Low-density Lipoprotein Cholesterol Levels in Subjects Undergoing Annual Health Examination in Japan
• Impact of Insufficient Insulin Secretion on Subclinical Glucose Dysregulation

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