Successful Allogeneic Hematopoietic Stem Cell Transplantation in a Young Patient with Richter Syndrome Presenting with Chronic Lymphocytic Leukemia and Diffuse Large B-Cell Lymphoma with Different Cell Origins
スポンサーリンク
概要
- 論文の詳細を見る
A 32-year-old woman was referred to our hospital due to systemic lymphadenopathy. The patient's peripheral blood showed expansion of CD5+CD20+CD38+CD23- mature lymphocytes. However, the axillary lymph nodes were infiltrated by both CD23+ large lymphocytes and CD23- small lymphocytes. Because the pattern of the rearranged immunoglobulin heavy chain gene was different between the peripheral blood and lymph node samples in a Southern blot analysis, the patient was diagnosed with Richter syndrome, in which diffuse large B-cell lymphoma develops from a clone distinct from B-cell chronic lymphocytic leukemia. After undergoing rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) therapy, the patient was successfully treated with allogeneic hematopoietic transplantation, and no relapse was observed for three years.
著者
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MORITA Yasuyoshi
Department of Hematology, Kinki University School of Medicine
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Rai Shinya
Department of Hematology, Kinki University School of Medicine
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Tatsumi Yoichi
Department Of Hematology Nephrology And Clinical Immunology Kinki University School Of Medicine
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Matsumura Itaru
Department Of Hematology And Oncology Osaka University Graduate School Of Medicine
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Ashida Takashi
Department Of Family And Child Nursing And Midwifery Shinshu University School Of Health Sciences
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Matsuda Mitsuhiro
Department Of Hematology Kinki University School Of Medicine
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Tanaka Hirokazu
Department Of Applied Physics National Defense Academy
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Ashida Takashi
Department of Hematology and Rheumatology, Kinki University Faculty of Medicine, Japan
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Yamairi Nozomi
Department of Hematology, PL General Hospital, Japan
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Eguchi Go
Department of Hematology, PL General Hospital, Japan
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Iwanaga Takayuki
Department of Hematology, PL General Hospital, Japan
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Morita Yasuyoshi
Department of Hematology and Rheumatology, Kinki University Faculty of Medicine, Japan
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Tatsumi Yoichi
Department of Hematology and Rheumatology, Kinki University Faculty of Medicine, Japan
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Rai Shinya
Department of Hematology and Rheumatology, Kinki University Faculty of Medicine, Japan
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Matsuda Mitsuhiro
Department of Hematology, PL General Hospital, Japan
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Matsumura Itaru
Department of Hematology and Rheumatology, Kinki University Faculty of Medicine, Japan
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