Cardio-Ankle Vascular Index Relates to Left Ventricular Ejection Fraction in Patients With Heart Failure:A Retrospective Study

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概要

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• The cardio-ankle vascular index (CAVI) has been proposed as a new noninvasive marker of arterial stiffness independent of blood pressure. Arterial stiffness is closely related to afterload, and elevated afterload aggravates heart failure. We hypothesized that CAVI is a potential marker of afterload in patients with heart failure. Thirty patients who were admitted because of acute heart failure were identified retrospectively from a review of clinical records. Plasma brain natriuretic peptide (BNP) levels, CAVI, cardiothoracic ratio (CTR), and echocardiographic parameters obtained during acute and chronic phases of heart failure were analyzed. Left ventricular ejection fraction (LVEF) increased significantly and CTR, BNP and CAVI decreased significantly after treatment of heart failure. A significant negative correlation was observed between the change in CAVI and change in LVEF in all subjects (<I>r</I> = -0.3272, <I>P</I> < 0.05). To examine the relationship between CAVI and LVEF, we divided the patients into two subgroups (∆CAVI < -0.5; CAVI decrease group, ∆CAVI ≥ -0.5; CAVI non-decrease group). CAVI was significantly improved after heart failure treatment only in the CAVI decrease group. LVEF decreased significantly in both groups, but the <I>P</I> value was smaller in the CAVI decrease group than in the CAVI non-decrease group. The change in LVEF correlated significantly with the change in CAVI in the CAVI decrease group (<I>r</I> = -0.4201, <I>P</I> < 0.05), whereas no significant correlation was found in the CAVI non-decrease group. CAVI correlates inversely with LVEF after heart failure treatment. Our results suggest that CAVI might partially reflect the afterload in patients with heart failure.

著者

• Iizuka Takuo

  Department of Cardiology, Toyohashi Heart Center

• Hirano Keiichi

  Department of Applied Physics, Faculty of Engineering, University of Tokyo

• OYAMA Tomokazu

  Center of Diabetes, Endocrinology & Metabolism, Sakura Hospital, Toho University School of Medicine

• ENDO Kei

  Center of Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University

• OHIRA Masahiro

  Center of Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University

• Sugiyama Yuko

  Department of Cardiovascular Center, Toho University Sakura Hospital

• Tomaru Takanobu

  Department Of Cardiology Toho University Sakura Hospital

• Shimizu Kazuhiro

  Department Of Dermatology Nagasaki University Graduate School Of Biomedical Sciences

• Wang Hongyu

  Department Of Cardiology People's Hospital Peking University

• Suzuki Masayo

  Departments Of Cardiovascular Center Sakura Medical Center School Of Medicine Toho University

• Mikamo Hiroshi

  Departments Of Cardiovascular Center Sakura Medical Center School Of Medicine Toho University

• Shirai Kohji

  Department Of Clinical Laboratory Medicine Sakura Hospital School Of Medicine Toho University

• Saiki Atsuhito

  Center Of Diabetes Endocrinology And Metabolism Sakura Hospital Toho University

• Nakagami Takahiro

  Departments Of Cardiovascular Center Sakura Medical Center School Of Medicine Toho University

• Noike Hirofumi

  Department Of Cardiovasucular Center Sakura Hospital Medical Center Toho University

• Takahashi Mao

  Department Of Cardiovascular Center Toho University Sakura Medical Center

• Hirano Keiichi

  Department of Cardiovascular Center, Sakura Hospital, Toho University Medical Center

• Tomaru Takanobu

  Department of Clinical Physiology, Sakura Hospital, Toho University Medical Center

• Zhang Chengmin

  Department of Cardiology, Zichuan District Hospital

• Yamaguchi Takashi

  Center for Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University Medical Center

• Kawana Hidetoshi

  Center for Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University Medical Center

• Kurosu Takumi

  Department of Clinical Physiology, Sakura Hospital, Toho University Medical Center

• Shirai Kohji

  Department of Vascular Function, Sakura Hospital, Toho University Medical Center

• Mikamo Hiroshi

  Department of Cardiovascular Center, Sakura Hospital, Toho University Medical Center

• Endo Kei

  Center for Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University Medical Center

• Takahashi Mao

  Department of Cardiovascular Center, Sakura Hospital, Toho University Medical Center

• Oyama Tomokazu

  Center for Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University Medical Center

• Shimizu Kazuhiro

  Department of Cardiovascular Center, Sakura Hospital, Toho University Medical Center

• Ohira Masahiro

  Center for Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University Medical Center

• Suzuki Masayo

  Department of Cardiovascular Center, Sakura Hospital, Toho University Medical Center

• Sugiyama Yuko

  Department of Cardiovascular Center, Sakura Hospital, Toho University Medical Center

• Nakagami Takahiro

  Department of Cardiovascular Center, Sakura Hospital, Toho University Medical Center

• Noike Hirofumi

  Department of Cardiovascular Center, Sakura Hospital, Toho University Medical Center

• Iizuka Takuo

  Department of Cardiovascular Center, Sakura Hospital, Toho University Medical Center

• Saiki Atsuhito

  Center for Diabetes, Endocrinology and Metabolism, Sakura Hospital, Toho University Medical Center

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