MicroRNA 210 as a Biomarker for Congestive Heart Failure
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概要
- 論文の詳細を見る
MicroRNAs (miRNAs) are endogenous small RNAs that are 18–23 nucleotides long. Recently, plasma miRNAs were reported to be sensitive and specific biomarkers of various pathological conditions. In the present study, we focused on miR-210, which is known to be induced by hypoxia and might therefore be an excellent biomarker for congestive heart failure. Plasma miR-210 levels and expression levels in mononuclear cells and skeletal muscles were elevated in Dahl salt-sensitive rats with heart failure. We also assessed miR-210 expression in patients with heart failure. The miR-210 expression levels in the mononuclear cells of patients with NYHA III and IV heart failure according to the New York Heart Association (NYHA) functional classification system were significantly higher than those with NYHA II heart failure and controls. Although no significant correlation was observed between plasma brain natriuretic peptide (BNP) and plasma miR-210 levels in patients with NYHA II heart failure, patients with an improved BNP profile at the subsequent hospital visit were classified in a subgroup of patients with low plasma miR-210 levels. Plasma miR-210 levels may reflect a mismatch between the pump function of the heart and oxygen demand in the peripheral tissues, and be a new biomarker for chronic heart failure in addition to plasma BNP concentrations.
著者
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Noguchi Teruo
Department Of Cardiology National Cardio Vascular Center
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Iwai Naoharu
Department Of Epidemiology National Cardiovascular Center
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FUKUSHIMA Yasue
Department of Epidemiology, Research Institute, National Cardiovascular Center
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Nakanishi Michio
Department Of Cardiology Kokura Memorial Hospital
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Goto Yoichi
Department Of Cardiology National Cardiovascular Center
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Ji Xu
Department Of Epidemiology Research Institute National Cardiovascular Center
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Hirokawa Go
Department Of Epidemiology Research Institute National Cardiovascular Center
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Endo Kosuke
Department Of Chemical Engineering Waseda University
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Yamaoka Tetsuji
Department Of Biomedical Engineering Advanced Medical Engineering Center National Cardiovascular Cen
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Nonogi Hiroshi
Department Of Cardiology Medical School Osaka University
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Kakinoki Sachiro
Department Of Biomedical Engineering National Cardiovascular Center Research Institute
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Naito Yukiko
Department Of Genomic Medicine National Cerebral And Cardiovascular Center
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Weng Huachun
Department Of Genomic Medicine National Cerebral And Cardiovascular Center
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Ma Xiao
Department Of Grassland Science College Of Animal Science And Technology Sichuan Agricultural University
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Fukushima Yasue
Department of Genomic Medicine, National Cerebral and Cardiovascular Center
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Asada Takashi
Department of Cardiovascular Medicine, Clinical Laboratory, National Cerebral and Cardiovascular Center
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Kakinoki Sachiro
Department of Biomedical Engineering, National Cerebral and Cardiovascular Center
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ASADA TAKASHI
Department of Applied Chemistry, Gufu University
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Ma Xiao
Department of Genomic Medicine, National Cerebral and Cardiovascular Center
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