Acute Changes in Inorganic Phosphorus, Urea, and Alkaline Phosphatase of Plasma and Glomerular Filtration Rate during the Development of Soft Tissue Calcification in KK Mice Fed on a Diet Low in Magnesium and High in Phosphorus

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It was previously reported that KK mice, when fed on a semi-synthetic diet low in magnesium and high in phosphorus, developed severe calcifications in soft tissues. Feeding this diet developed for only a few days such various changes as renal calcification, a decrease in glomerular filtration rate, a decrease in disappearance rate of plasma urea, hyperuremia, hyperphosphatemia, calcification of the heart and other soft tissues, and a decrease in alkaline phosphatase activity subsequent to a transient elevation. These changes were closely related each other and developed in the order as stated above. Since the changes were completely prevented by supplement of magnesium alone, relative deficiency of dietary magnesium is a major causal factor. However, all of these changes never developed in the control ICR mice. A systemic study on the KK mice maintained on the diet revealed that the reduction of glomerular filtration rate which has been caused by deposition of calcium salts within the renal tubules resulted in development of hyperuremia and hyperphosphatemia. Hyperphosphatemia brought about a rise in product of Ca×Pi, which was the main cause of the soft tissue calcification such as the heart and others.
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