Relationship Between Body Fat Distribution and Serum Level of Uric Acid in Obese Children.

概要

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This study is examined serum levels of uric acid in obese children to determine the relationship to regional distribution of body fat. Subjects included 60 obese children (11 girls and 49 bodys, ranging in age from 10 to 15 years). Fat distribution was evaluated by calculating the ratio of visceral fat area to subcutaneous fat area on CT scan at the umbilical level (V/Sratio). Insulin sensitivity was assessed by Σ glucose/Σ insulin on oral glucose tolerance test. Uric acid clearance was evaluated by determining the fractional excretion of uric acid (FEUA). Serum levels of uric acid correlated positively with V/S ratios. FEUA in the group with greater visceral fat was significantly lower than that in the group with greater subcutaneous fat. FEUA correlated significantly with the magnitude of insulin sensitivity. The magnitude of insulin sensitivity correlated inversely with V/S ratios. These results suggest that the excess accumulation of visceral fat may decrease uric acid clearance resulting in the progression of hyperuricinemia in childhood obesity.
Japanese Society of Gout and Nucleic Acid Metabolismの論文