Plasma Thromboxan B<SUB>2</SUB> in Ischemic Cerebrovascular Diseases
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Plasma thromboxane B<SUB>2</SUB> (TXB<SUB>2</SUB>) in ischemic cerebrovascular diseases and other diseases were measured and its relation to the period after onset (or last attack) and to aspirin (ASP) treatment was studied. Platelet aggregation was examined simultaneously in some cases.<BR><I>Object</I>: For TXB<SUB>2</SUB>, transient ischemic attack (TIA) 8 cases (11 measured), cerebral infarction 18 cases (19 measured), cerebral bleeding 2 cases, epilepsy 2 cases and normal healthy control 24 cases were measured. For platelet aggregation, 4 cases of TIA, 8 cases of cerebral infarction and other 3 cases were examined.<BR><I>Assay methods</I>: TXB<SUB>2</SUB> was extracted from heparinized plasma by ethyl acetate, purified by thin layer chromatography and assayed by radioimmunoassay. Platelet aggregation was examined from sodium citrate-mixed blood by absorption method for ADP (2×10<SUP>-5</SUP>M) and collagen (3μg/ ml)<BR><I>Result</I>: Plasma TXB<SUB>2</SUB> (mean±SD) was as follows, control: 155±35pg/ml; TIA: ASP nontreated: 260±215 (6 measurement), ASP treated: 52±41 (4); <I>cerebral infarction</I>: within one month after onset: ASP non-treated: 1750±1310 (4), ASP treated: 42 (2), over one month after onset: ASP non-treated: 59±35 (7), ASP treated: 64±16 (3); <I>cerebral bleeding</I>: 6 days after onset: 1120, 9 months after onset: 165, <I>epilepsy</I>: one day after attack: 626, one month after attack: 298.<BR>In eschemic cerebrovascular diseases (TIA and cerebral infarction) logarithmically converted values of both TXB<SUB>2</SUB> and the period (days) after onset were correlated signifcantly (correlation coefficient -0.77, N=15, p<0.01). Seven paired TXB<SUB>2</SUB> values of ASP non-treated and treated cases, measured at the same time after onset, were selected. Their means and SD were 236±205 in ASP non-treated and 51±23 in ASP treated cases. It's difference was not significant. 2 cases over 90% absorption in platelet aggregation for both ADP and collagen (TIA and epilepsy) gave high TXB<SUB>2</SUB> values (3320 and 298 respectively) and other 13 cases under 90% had normal values.<BR><I>Conclusion</I>: Plasma TXB<SUB>2</SUB> increased in ASP non-treated cases of TIA and those of cerebral infarction within one month after onset. Each case after cerebral bleeding and convulsion gave also high plasma TXB<SUB>2</SUB> values. Increased platelet aggregation was found in 2 cases showing high plasma TXB<SUB>2</SUB> values.
- Japan Society of Clinical Chemistryの論文
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