Excereise-induced Hyperuricemia(2):-Effect of Weight Training on Uric Acid Metabolism-

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The purpose of this study was to examine the effects of weight training on uric acid metabolism. The subjects were eight male students training regularly. The weight training program consisted of dead- lift, bench- press and half - squat. The load weight used in the experiments was 30%,60% and 80% load weight of the maximum muscle strength of each subjects. The subjects exercised with each to ad until exhaution. One subject continued weight training with 30% or 80% load for a weak, respectively.<BR>Increases in ser um uric acid and blood lactate were significantly higher with 30% and 60% loads than with 80% load, but that of urinary excretion of uric acid was not. In contrast, serum creatine phosphokinase was significantly higher with 80% load than with 30% and 60% loads. There were no significant differences in uric acid clearance among the three experiments.<BR>Serum uric acid with 30% load continued to incre ase for a week with 30% load, but not with 80% load. The mean urinary excretion of uric acid for a week was 963±122 mg/day with 30% load and 559±90 mg/day with 80% load.<BR>These results suggest that the main cause of increased serum uric acid with 80% load is injury of muscle tissue and the main cause with 30% and 60% loads is increased degradation of skeletal muscle ATP.
Japanese Society of Gout and Nucleic Acid Metabolismの論文