STUDY OF EFFECT OF NEO RED CELLS ON HEMODYNAMICS AND BLOOD GAS TRANSPORT IN CANINE HEMORRHAGIC SHOCK.

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概要

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• The purpose of this study is to evaluate the newly developed liposome-encapsulated hemoglobin named Neo Red Cells (NRC) in the treatment of hemorrhagic shock. These cells are produced using a lipid bimolecular membrane. The particle size of NRC is 0.2nm, the methemoglobin rate is less than 5% and the hemoglobin concentration is 5.6g/dl. The experiment was carried out on six mongrel dogs suffering hemorrhagic shock. After 59% to 88% blood exchange using NRC, the blood gas was analyzed, the hemodynamics measured and various laboratory examinations were carried out. hemodynamic findings: the total peripheral vascular resistance index (TPRI) was reduced and the cardiac index (CI) was increased thereby alleviating the burden on the heart. That the TPRI was reduced in the presence off hemorrhagic shock is presumed to be due to the small size of the NRC granules and their low viscosity. As the exchange rate increased, the oxygen consumption (VO2) increased remarkably, presumably due to the increase of CI and the A-V difference of oxygen content. When the exchange rate was 88% the NRC-hemoglobin VO2 was 60.4%. The conclusion of the study is that NRC is suitable as artificial blood for the treatment of hemorrhagic shock.

• 一般社団法人 日本人工臓器学会の論文

著者

• 井上 仁

  First Department of Surgery, Fukushima Medical College

• 遠藤 幸男

  First Department of Surgery Fukushima Medical College

• 宮沢 正紹

  First Department of Surgery Fukushima Medical College

• 元木 良一

  First Department of Surgery Fukushima Medical College

• 薄場 彰

  First Department of Surgery Fukushima Medical College

関連論文

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• STUDY OF EFFECT OF NEO RED CELLS ON HEMODYNAMICS AND BLOOD GAS TRANSPORT IN CANINE HEMORRHAGIC SHOCK.

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