THE EFFECT OF GABEXATE MESILATE ON COAGULOFIBRINOLYTIC SYSTEM AND PLATELET FUNCTION DURING EXTRACORPOREAL CIRCULATION

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概要

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• The effect of Gabexate Mesilate (GM) on the coagulofibrinolytic system and platelet function was investigated in 25 patients undergoing CABG or valve replacement under extracorporeal circulation (ECC). In group G (11 patients), GM (40mg/kg/hr) was administrated during ECC, while group C (14 patients) had no administration of GM. In both groups heparin (4mg/kg) was administrated before the start of ECC. PT (%) was less in group G than in group C during ECC. But after ECC, PT (%) was higher in group G. AT III was higher in group G than in group C during and after ECC. EDP and D-dimmer were significantly greater in group C than in group G after ECC. Platelet aggregation function was more recovered after ECC in group G when compared to group C. There was no significant difference of fibrinolitic activity between these two groups. These results suggested that GM suppressed coagulation activity through ECC in cooperation with heparin and protected platelet function.

• 一般社団法人 日本人工臓器学会の論文

著者

• 佐々木 裕茂

  First Department of Surgery, Gifu University, School of Medicine

• 村川 真司

  First Department of Surgery, Gifu University, School of Medicine

• 森 義雄

  First Department of Surgery, Gifu University, School of Medicine

• 山田 拓

  First Department of Surgery, Gifu University, School of Medicine

• 東 健一郎

  First Department of Surgery, Gifu University, School of Medicine

• 酒井 聡

  First Department of Surgery, Gifu University, School of Medicine

• 小久保 光治

  First Department of Surgery, Gifu University, School of Medicine

• 梅田 正五

  First Department of Surgery, Gifu University, School of Medicine

• 広瀬 一

  First Department of Surgery, Gifu University, School of Medicine

関連論文

• THE EFFECT OF GABEXATE MESILATE ON COAGULOFIBRINOLYTIC SYSTEM AND PLATELET FUNCTION DURING EXTRACORPOREAL CIRCULATION

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