Potential of BNP as a Biomarker to Predict Prognosis of the Patients Who Underwent Catheter Ablation to Persistent and Chronic Atrial Fibrillation
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概要
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<B>Background:</B> Recently, we expect expansion of indication for catheter ablation (CA) to atrial fibrillation (AF), because of improving success rate of that. Whereas, there aren’t no significant difference in prognosis between rhythm control and rate control of AF by pharmacotherapy, so that importance of maintaining sinus rhythm (SR) in the patients with AF couldn’t be proved. Then we evaluated efficacy of CA to persistent and chronic AF (PEF&CAF) using Brain Natriuretic Peptide (BNP). <B>Objects:</B> Fifty one patients were performed CA to PEF&CAF (Male 41 cases, Mean age 56.5±9.4, Persistent; 37 cases (46 procedures), Chronic; 14 cases (18 procedures)). <B>Methods:</B> The cases maintained SR without anti-arrhythmic drugs (AADs) were in SR group, the another ones with SR on AADs were in AADs group, and the others under rate control to AF were in AF group. BNP was gathered the highest one (PreBNP) within 3 months before ablation, and the lowest one (PostBNP) between 3 and 6 months after ablation. <B>Results:</B> PreBNP had no significant difference among each group, but PostBNP in SR and AADs group was reduced significantly compared with AF group (27.6±27.4 pg/ml in SR group, 39.4±23.0 pg/ml in AADs group, and 92.9±97.7 pg/ml in AF group, p=0.0002)). <B>Conclusions:</B> CA to PEF&CAF made PostBNP significantly reduced in rhythm control groups compared with rate control group. This study suggests that rhythm control by CA to PEF&CAF has possibility to improve prognosis of the patients with AF.
著者
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Sato Akira
Cardiovascular Center Yokosuka Kyosai Hospital
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Junichi Nitta
Cardiovascular Division, Saitama Red Cross Hospital
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Sato Akira
Cardiovascular Division, Saitama Red Cross Hospital
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