ラット腱板断裂モデルにおける行動 • 疼痛評価

概要

論文の詳細を見る
Background: The purpose of this study was to evaluate the behavior and the inflammatory cytokines (TNF-α)in the rat rotator cuff tear model. Methods: Twenty-five Sprague-Dawley rats were divided into four groups: 1)control (before experiment), 2)sham, 3)rotator cuff tear (RCT), and 4)rotator cuff repair (RCR) groups. Stride Length was examined using catwalk as a behavioral evaluation. Moreover, inflammatory cytokine was measured in the synovia of the subacromial bursa and the glenohumeral joint at 3 and 8 weeks after the surgery using the ELISA method. Results: Stride length in the RCT group was decreased at 3 days, 1, 2 and 3 weeks after surgery compared to the control group (p<0.05). On the other hand, stride length in the RCR group was decreased only 3 days after the surgery compared to the control group (p<0.05). Stride length in the RCR group was increased at 1, 2, and 3 weeks after the surgery compared to the RCT group (p<0.05). TNF-α in the RCT group was increased compared to the control and RCR groups (p<0.05). Conclusion: These dates showed that the repair of the rotator cuff was effective in not only the improvement of shoulder function but also the reduction of inflammatory cytokines (TNF-α). These data also showed that the inflammatory cytokines (TNF-α)may be one of the pain mechanism in the rotator cuff tear.