多孔質バイオセラミックス人工骨の圧縮力学特性に及ぼすコラーゲンコーティングの影響 (特集傾斜機能・生体材料)

概要

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Recently, in the field of orthopedics, artificial bone substitute has been one of the primary concerns instead of autografts and allografts. The ideal artificial substitutes are biodegradable with adjustable degradation rate that fits in the rate of tissue regeneration and also need enough mechanical properties to support the part of bone defect. In this study, a porous structure of <I>β</I>-TCP was fabricated and collagen coating was introduced to enhance the structural stability and mechanical properties. Compressive mechanical tests were performed to assess the effect of the collagen coating, and the surfaces of the specimens were also observed using FE-SEM to understand the microstructural modification. It was found that the compressive modulus and strength of the porous <I>β</I>-TCP can be effectively improved by collagen coating.