Arrangement of PC12 Cells on a Silicon Chip via Extracellular Matrix (ECM) Layer Patterning by Atmospheric Pressure Plasmas

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概要

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• It is shown that neuronal model cells PC12 (rat adrenal pheochromocytoma cell line) can be cultured on a silicon (Si) substrate with the use of extracellular matrix (ECM) patterned by atmospheric-pressure plasmas (APPs). Arrangement of neuron cells in a desired pattern on a Si chip is an important step for the development of neuron cell chips. In the experiments, 100-200 µm wide strips of ECM (Poly-L-Lysine) layers arranged in parallel were formed on a 1 cm2 area of a Si surface by the APP etching technique and PC12 cells were shown to grow on the ECM strips. The APP etching technique for ECM layers provides a simple mean of arranging neuron cells on a relatively large area of a Si surface.

著者

• Hamaguchi Satoshi

  Center For Atomic And Molecular Technologies Graduate School Of Engineering Osaka University

• Ando Ayumi

  Center for Atomic and Molecular Technologies, Osaka University, Suita, Osaka 565-0871, Japan

• Asano Toshifumi

  Division of Neuroscience, Department of Developmental Biology and Neurosciences, Tohoku University, Sendai 980-8577, Japan

• URISU Tsuneo

  FIRST Research Center for Innovative Nanobiodevice, Nagoya University, Furo-cho, Chikusa, Nagoya, Aichi 464-8603, Japan

• UNO Hidetaka

  FIRST Research Center for Innovative Nanobiodevice, Nagoya University, Furo-cho, Chikusa, Nagoya, Aichi 464-8603, Japan

• ASANO Toshifumi

  Division of Neuroscience, Department of Developmental Biology and Neurosciences, Tohoku University, 2-1-1 Katahira, Aoba, Sendai, Miyagi 980-8577, Japan

• ANDO Ayumi

  Center for Atomic and Molecular Technologies, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan

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• Arrangement of PC12 Cells on a Silicon Chip via Extracellular Matrix (ECM) Layer Patterning by Atmospheric Pressure Plasmas

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