Psychotropic Drugs and Electrocardiogram in Schizophrenic Patients

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概要

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• The influence of psychotropic drugs upon electrocardiographic findings was studied in 104 hospitalized schizophrenic patients, 52 for each sex, receiving the combination-therapy of psychotropic agents.<BR>The results obtained were as follows:<BR>1) The doses of chlorpromazine, levomepromazine, thioridazine, perphenazine and haloperidol possessed significant correlations with the prolongation of the Q-T interval, and the doses of chlorpromazine, levomepromazine, promethazine and biperiden with the increase in heart rate.<BR>2) The interaction between the dose of promethazine and some factor (s) related with sex showed a significant correlation with the Q-T interval prolongation, and the interaction between the dose of biperiden and some factor (s) related with sex showed with the heart rate increase.<BR>3) With the increase in the doses of major tranquilizers, the frequency of the T-wave change was increased, the Q-T interval was prolonged, and the heart rate was elevated.<BR>4) The correlation of the T-wave change and psychotropic drugs was less evident than those of Q-T interval and of the heart rate.

• 一般社団法人 日本臨床薬理学会の論文

著者

• Hattori Takao

  Department of Applied Chemistry, Faculty of Science and Technology, Keio University

• HATTORI Takao

  Department of Clinical Pharmacology, Medical Research Institute, Tokyo Medical and Dental University

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