Effects of amlodipine on Hemodynamic and Hormonal Responses to Exercise in Patients with Essential Hypertension.

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The effects of amlodipine, a Ca2+-channel blockade, on hemodynamic and hormonal responses to exercise were evaluated in patients with essential hypertension. In 7 patients (WHO stage, I, II), the exercise by bicycle ergometer was done before and after amlodipine treatment (5mg/day, 2-4wk). The hemodynamic responses to exercise were evaluated by changes in systolic and diastolic blood pressure, heart rate, cardiac output measured by UCG, and total peripheral resistance. In addition, plasma norepinephrine concentration (PNE) and renin activity (PRA) were measured at rest and peak exercise. A significant rise in systolic and diastolic blood pressure associated with tachycardia was observed during exercise. An increase in cardiac output was also observed, but the total peripheral resistance decreased by exercise. The PNE and PRA were increased by exercise. Amlodipine reduced both basal blood pressure and exercise-induced rise in blood pressure. On the other hand, the basal heart rate and exercise-induced increase in heart rate were not affected by amlodipine treatment. These changes were similar to those in pretreatment of amlodipine. Amlodipine did not produce any significant changes in PNE both at rest and during exercise. Although the PRA at rest was increased by amlodipine treatment, the increase in PRA induced by exercise was unaffected by amlodipine. These findings indicate that amlodipine might have some different effects on hemodynamics and hormones compared with the other Ca2+-channel blockades which produce an enhanced response of hemodynamics and hormonal system to exercise.

Effects of amlodipine on Hemodynamic and Hormonal Responses to Exercise in Patients with Essential Hypertension.

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