Pharmacokinetics of Serum rhG-CSF Levels in HIV-Positive Hemophiliacs with Neutropenia.

スポンサーリンク

概要

• 論文の詳細を見る

• It is known that approximately 20-50% of acquired immunodeficiency syndrome (AIDS) patients are neutropenic and the cause of the neutropenia has not been conclusively elucidated. From 1993 to 1994, a pharmacokinetic study of single-dose rhG-CSF at5μg/kg i. v. was carried out to investigate the correlation between neutrophil counts andserum rG-CSF level using enzyme immunoassay (ETA) in 6 human immunodeficiencyvirus (HIV) patients with the following:<BR>(A) chronic neutropenia (<1, 000/μl) for over 6 months in 5 patients<BR>(B) septicaemia accompanied with acute neutropenia in 1 patient<BR>In Class A, the serum concentration of G-CSF was undetectably low, and less than themeasurement limit (30.0 pg/ml) in 4 out of 5 patients. In Class B, the serum G-CSF levelwas 5, 830 pg/ml. The neutrophil count reached the maximum level at 8 hours afteradministration of rhG-CSF and the neutrophil count remained higher than the preadministration level at 24 hours after the administration. A transient decrease in themonocyte count was observed 1 hour after the rhG-CSF administration in 5 out of 6patients. No effect was observed in the other WBC differentials. Pharmacokinetic profileof rhG-CSF obtained in this study (Class A/B) are summarized as follows ;<BR>*T<SUB>1/2</SUB> (α) =1.66±0.47/1.14 (h)<BR>*T<SUB>1/2</SUB> (β) = 3.32±0.66/3.85 (h)<BR>*V<SUB>c</SUB>=38.66±6.48/26.38 (ml/kg)<BR>*AUC (0-24) = 1201.73±560.06/995.46 (pg⋅h/ml)<BR>*CL=10.78±3.61/11.4 (ml/h/kg)<BR>Further, the serum rG-CSF concentration decreased biphasically. In conclusion, it wasfound that excretion, transformation and inactivation of G-CSF was not enhanced inHIV-positive hemophiliacs who showed neutropenia. It was suspected that a productiondisorder of G-CSF might be a factor in neutropenia in patients with chronic neutropenia (Class A), because the serum G-CSF concentration was low in these patients.

著者

• 花房 秀次

  荻窪病院小児科

関連論文

• 難治性川崎病に合併した高度難聴の1例
• 好中球減少症を呈した血友病HIV感染者における遺伝子組換え型ヒト顆粒球コロニー形成刺激因子(rhG-CSF)の血清中濃度推移の検討
• 後天性血友病A診療ガイドライン
• Pharmacokinetics of Serum rhG-CSF Levels in HIV-Positive Hemophiliacs with Neutropenia.
• 日本血栓止血学会後天性血友病A診療ガイドライン

スポンサーリンク