EXPERIMENTAL STUDY ON THE FUNCTIONAL AND HISTOLOGICAL CHANGES OF THE LIVER CAUSED BY THE ACID HOT SPRING BATHING AT TAMAGAWA SPA
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The author made a research on the biochemical, histological and serological effects of the acid hot spring bathing at Tamagawa Spa (a acid vitriol sulphur spring) on the liver of rabbits. The condition of the bathing was to shave the back of rabbits and to give them a serial bathing for 10 days (10 minutes once a day at 42-43°C), and as control to give other rabbits a fresh water bathing under the same condition as mentioned above.1. Functional changes of the liver.1) Blocd sugar: The group of the hot spring bathing showed same wavy changes of blood sugar values as the group of the fresh water bathing, while there was a difference in the phase of the change between the two groups.2) Blood plasma protein fractions: Following changes were observed-decrease of T. P. in the early stadium and its later increase, increase of Globulin, decrease of Albumin with its lowest value in the middle stadium and its gradual recovery in the later stadium, increase of α-Gl, β-Gl and φ with their peaks in the middle stadium, and decrease of γ-Gl in the early stadium and its later gradual increase.3) Iodate reducing power of the blood: It showed no definite change in the early stadium of bathing, and then it took a tendency of increase as days of the bathing went on, but it restored to its normal state soon or later after the 10 days' serial bathing was over.4) Serum Co-reaction: Serum cobalt changed positive to the leftside in both groups, but in the group of hot spring bathing it was stronger than in the group of the fresh water bathing.5) Blood cholesterol: Total-cholesterol-and free-cholesterol-values decreased during the whole course of the serial bathing, while ester-cholesterol-values showed a gradual increase taking a wavy change. E. Q. (%) increased, therefore, during the whole course of the serial bathing.6) Liver V. B2: In the early stadium decrease of total-V. B2 and FAD, and increase of FMN and FR were observed, but in the middle and the later stadium increase of total-V. B2 and FAD, and decrease of FMN and FR were observed. These later changes were still more remarkable after the 10 days' serial bathing was over.7) BSP-test: BSP-test showed negative reaction in both groups.8) The phagocytosis of trypan-blue by Kupffer's stellate cells: At the early stadium of bathing it decreased for a while, and then gradually increased and remarkably increased at the beginning of the later stadium.2. Histological changes.a) In the liver it was proved that the swelling and increase of Kupffer's stellate cells and the infiltration of the mononuclear cells in Glisson's sheaths were more remarkable in the group of the hot spring bathing than in the control group.The increase of Kupffer's stellate cells was almost parallel with that of phyagocytosis of the trypan-blue. The swelling and cloudiness of the liver cells and the hyperemia of the liver were a little stronger in the group of the hot spring bathing than in the control group.b) In the kidney, the hyperemia of the kidney and the swelling, cloudiness of the epithelium of uriniferous tubules and its desquamation in the group of tho hot spring bathing were stronger than those in the control group.c) In the spleen and lymph nodes, the reticulo-endothelial cells increased, but it was difficult to observe the differences of degree between the two groups.d) In the bone-marrow, the hematopoesis was a little stronger in the group of the hot spring bathing than that in the group of the fresh water bathing.The histological changes of these organs gave almost common histological findings in both groups except their quantitative differences, and they were observed to be momentary and reversible.3. Patho-anatomical findings in the parts affected by the dermatitis at Tamagawa Spa, and serological and biochemieal studies on the production of the auto-antiobody.1) The occurrence of the
- 一般社団法人 日本温泉気候物理医学会の論文
一般社団法人 日本温泉気候物理医学会 | 論文
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