AGING PHENOMENON OF HOT SPRING WATERS AND THEIR EFFECTS ON THE IMMUNE REACTIONS IN RABBITS:Report I. Effects on Local Immunity in Subcutaneous Tissue

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It has been said that hot spring water shows an aging phenomenon by which "virgin" water looses their original characters and eventually becomes "old" water.Using waters collected from Gero Hot Springs, Yuya Mineral Spring and their ground waters, effects on local subcutaneous immunity were examined in rabbits. Following the observation of development of aging phenomenon in these waters, comparative studies of "virgin" and "old" waters were made in regard to local immunity and following results were obtained.1) Samples of three simple and one hydrogen sulphide hot springs of Gero were examined. In their virgin states, all the samples powerfully stimulated the local immunity in subcutaneous tissue. This was evidenced by the phagocytosis in the subcutaneous tissue cells. This stimulation was not exhibited by the samples in aged states.2) Yuya Mineral Spring Water showed some stimulating effects, but practically no effect was obtained in aged condition.3) Ground water showed no stimulating effect in either "virgin" or "old" state.
一般社団法人日本温泉気候物理医学会の論文