EFFECTS OF 2, 4, 6-TRIHYDROXYPROPIOPHENONE ON THE MOTILITY OF BILE DUCT AND URETER
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The effects of new antispasmodic drug, 2, 4, 6-trihydroxypropiophenone (THPP) on the motility of bile duct, ureter and the colon were examined.<BR>1) Spontaneous contraction of the isolated bile duct was inhibited and tonus was markedly decreased by the administration of THPP at doses greater than 8×10<SUP>-5</SUP> g/ml. To provoke this spasmolytic effect on the isolated ureter a dose of 4×10<SUP>-4</SUP> g/ml was necessary.<BR>2) Spasms provoked by acetylcholine, BaCl<SUB>2</SUB> and serotonin were inhibited by THPP. Antispasmodic action of THPP against the evoked spasm by serotonin was stronger than that against the spasm by acetylcholine or BaCl<SUB>2</SUB>.<BR>3) The ureter and the bile duct were perfused with Ringer-Krebs solution and the amount of outflow was measured. The outflow from ureter periodically decreased at the automatic contraction. The outflow of ureter and that of bile duct decreased at the appiciation of acetylcholine, BaCl<SUB></SUB>2 or serotonin. because of the increase in muscle tonus. But when THPP was given the outflow increased because of its antispasmodic action. 4) The frequency of automatic contractions of the isolated ureter was the greatest at the inner pressure of 20 cm H<SUB>2</SUB>O. But in case of the bile duct the inner pressure was 14 cm H<SUB>2</SUB>O.
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