THE EFFECTS OF N-METHYL-HYOSCINE METHYL SULFATE (DD-234 or 1290 CERM) UPON THE GASTROINTESTINAL MOTILITY AND SALIVATION
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1) The intravenous administration of DD-234 (5-10μg/kg) inhibited the motilities of the stomach and small intestine of dogs, and the drug (20μg/kg) abolished the excitatory effect of vagal stimulation upon the gastric motility. The administration of the drug into the duodenal lumen inhibited also the vagal excitatory effect.<BR>2) In the isolated rectum and small intestine of dogs, the drug depressed the excitatory effect produced by applying acetylcholine, while that caused by administration of his-tamine or BaCl<SUB>2</SUB> was never inhibited.<BR>3) The salivation from the submandibular gland produced by stimulation of chorda tympani was absolished by administration of the drug.<BR>4) It may be concluded from the results described above that the drug has an anticholinergic activity.
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