EFFECTS OF PROSTAGLANDIN E1 ON CANINE GASTROINTESTINAL MOTILITY IN VIVO AND HUMAN ISOLATED SMOOTH MUSCLE IN VITRO.

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The present study was undertaken to investigate some of the effects of prostaglandin E1 ongastrointestinal motility in dogs and human isolated smooth muscle strips. Electromyographyand intraluminal manometry were used in the former and kymography in the latter. The results obtained were as follows: 1. In dogs, the intravenous injection of 0.25 to 2.0 μg/kg of PGE1 caused the potentiation of peristaltic movement and the increase in electrical activity of small intestine. 2. At higher doses (more than 2.5 μg/kg) of PGE1, the generation of action potential was rather depressed and peristaltic movement was also abolished. However, the intraluminal pressures recorded from the various portions of gastrointestinal tract always showed the patterns of contraction. 3. Discrepancies in results between EMG and manometry have been attributed by Bennett and his colleagues to the constrictive response of longitudinal muscle which is greater than the relaxing response of circular muscle. 4. Circular muscle strips of human stomach and colon usually showed the inhibition of activityby PGE1 in the concentration of 10-8 to 10-5 g/ml. On the other hand, longitudinal muscle strips showed the contraction patterns in the same concentration range of PGE1, but, in most cases, slight relaxations were observed before the contraction.
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