Desensitization for Antiepileptic Drug-induced Rash.

概要

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A whole-body rash, developing in patients receiving antiepileptic drugs, is not common but usually necessitates withdrawal of the drug. We report our experience with 5 patients who developed a whole-body rash shortly after the introduction of an antiepileptic drug and were treated by desensitization to the drug. We reintroduced carbamazepine in 3 cases, phenytoin and valproate in one case respectively. Four patients had had failure of seizure control with other antiepileptic drugs. Two patients had been in delusional-hallucinatory state. In 4 patients reintroduction of the antiepileptic drug treatment in full dose was achieved without whole-body rash while one had to discontinue the drug. In two cases delusional-hallucinatory state improved with reintroduction of carbamazepine. This study shows that desensitization for antiepileptic drug-induced rash is effective in the treatment of patients with severely refractory epilepsy.
一般社団法人日本てんかん学会の論文