Differential Diagnosis between Progressive Myoclonus Epilepsy and Juvenile Myoclonic Epilepsy at the First Out-patient Investigation.

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In the early stage of a certain group of the progressive myoclonus epilepsy (PME), several salient clinico-electroencephalographic features lead easily to confusion with juvenile myoclonic epilepsy (JME): 3-4 Hz irregular polyspike-wave complex, combination of myoclonic and generalized tonic clonic seizures, and photosensitivity. Wetried to prevent this confusion in this early stage of the illness by elucidating differences between PME and JME. Thirteen PME-as well as twenty JME-patients werechosen among all the 3165 out-patients refered to us as having epilepsies. In the current study, only the first EEG of each case was analysed because this study was concentrated on improving the initial diagnosis among out-patients. The comparison betweenthe two groups revealed following characteristics of the PME-group with statistically significant difference: lack of GTC on awakening, slowing of the basic rhythm, and abundance of bursts of spike & wave complexes. The last feature was measured by a number of the bursts of spike & wave complex within thirty seconds from the onset of the first spike & wave in a given record. These points of differential diagnosis confirmed here would be useful in preventing the misdiagnosis of PME as JMEespecially in the early stage of the developing PME.
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