Relationships of Secondarily Generalized Seizures and Morphometric Change in Dentate Gyrus to the Acquired Seizure Susceptibility in Amygdala Kindled Rats.
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This study examined the hypothesis of Reynolds that the a total number of seizures before treatment may be a key factor for seizure outcome. Three groups of amygdala kindled rats: the partial kindling group, the kindling group and the overkindling group with 30 stage 5 convulsions were used. After 50 days of stimulus-free intervals, seizure stages reduced in the partial kindling group and the kindling group with a kindled convulsions, while it was unchanged in the kindling group with 10 kindling convulsion. It is suggested that seizure susceptibility may increase after repetition of fully kindled convulsions in standard kindling procedures. In second, Timm score and neuronal density in the hilar polymorphic region of hippocampus were measured in these three kindling groups and control, which received 3Hz stimuli without induction of afterdischarges during the kindling sessions. No difference was found in the distribution of Timm granule between control and the kindling groups. The number of polymorphic neurons in the hilus reduced significantly in the kindling group as compared to control. Timm granule distribution in the over-kindled group increased more than other two kindling groups. It is shown that the mossy-fiber sprouting is not essential for the seizure development in amygdala kindling. It is also suggested that cell loss in the hilus may occur prior to the mossy fiber sprouting in the amygdala kindling.
- 一般社団法人 日本てんかん学会の論文
一般社団法人 日本てんかん学会 | 論文
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