The Relationship between Serum Theophylline Concentration and Urine Theophylline Metabolites in Asthmatic Children-A Comparison between Two Groups with Unchanged and Decreased Plasma Concentration.:A Comparison between Two Groups with Unchanged and Decrea

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Some patients show a decrease in plasma theophylline (TP) concentration, even when they are administered TP at a constant infusion rate. We measured the plasma and urinary concentration of TP and its three metabolites daily for 3 days, and examined the relationship between decreases in plasma TP concentration and the hepatic capacity of TP metabolism measured by the ratio of metabolites to TP in urine in 35 children with bronchial asthma. Patients were divided into two groups, and while one group showed a 10% or more decrease in plasma concentration over 3 days (n=15), the other showed no significant change (n=20). In the decreased group, the urinary ratios of two metabolites to TP increased during 3 days of treatment, while they remained unchanged in the unchanged group. These results suggested that an increase in hepatic metabolism of TP may contribute to significant decrease in plasma TP concentration in 40% of patients receiving a constant infusion of TP.