Localization of the Epileptic Focus by Dipole Tracing Method of an Inhomogeneous Realistic Head Model. 'Distribution of Equivalent Current Dipoles Around the Organic Lesion'.:Distribution of Equivalent Current Dipoles Around the Organic Lesion

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Purpose: To evaluate the usefulness of dipole tracing method with realistic head model, we examined the locations of equivalent current dipole (ECD) around the organic lesion cases.<BR>Subjects and Method: Five organic lesion cases were evaluated in this study. For the accuracy of data, we used dipole tracing method of realistic head model with inhomogeneous electrical conductivity, superimposed ECD over the realistic head model (ECD, dipolarity>0.98), and calculated the ECD concentration around the lesion.<BR>Results: Most of ECDs were located around the lesion in all cases. The ECD concentration ratio was ranged from 70 to 90% within 20 mm around the lesion.<BR>Neuroimaging examination showed clear margin of the organic lesion, a correlated to the scalp EEG showed spikes from the electrodes located near the lesion. Based on these preoperative evaluations, the organic lesion was totally resected. Four patients have been seizure free, and one patient has had seldom seizure after the operation (mean follow-up term 25 month).<BR>Conclusions: Dipole tracing method of a realistic head model appeared to be useful to estimate the epileptogenic zone. Seventy percent of ECDs within an area 20 mm apart from the lesion are necessary, provided neuroimaging and scalp EEG, concordant results are found, there0fore, epilepsy could be controlled by a simple lesionectomy.
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