Prognosis of complex partial seizures in children. Analysis of clinico-electroencephalographic features prognostic of poor seizure outcome.:Analysis of Clinico-electroencephalographic Features Prognostic of Poor Seizure Outcome

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Clinico-electroencephalographic features prognostic of poor seizure outcome were studied in 87 children with complex partial seizures (CPS). The clinico-electroencephalographic features of the 38 patients with seizure control and the 49 patients with persistent seizures were compared by chi-square test. The compared clinico-electroencephalographic features were (1) age at onset of seizures, (2) past history of febrile convulsion or status epilepticus, (3) experience of other type of seizures, (4) seizure frequency more than 2 per day, (5) symptomatic etiology, (6) mental retardation, (7) abnormal background activity, (8) focus of seizure discharges. A number of clinico-electroencephalographic features were shown to be of prognostic relevance. The clinico-electroencephalographic features prognostic of poor seizure outcome were (1) age at the first seizure≤2 yr. o., (2) symptomatic etiology, (3) mental retardation, (4) abnormal background activity, and (5) Ti, T2, focus. The number of these clinico-electroencephalographic features in each child related significantly to seizure control. In 21 patients who had no these clinico-electroencephalographic featuress, only 4 showed persistence of seizures. While the persistence of seizures was observed in 82.4%-91.9% of 28 patients who had more than three these clinico-electroencephalographic features.
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